Emergence of a Predictive Clinical Biomarker for Diabetic Neuropathy
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چکیده
منابع مشابه
Emergence of a Predictive Clinical Biomarker for Diabetic Neuropathy
Diabetes is often complicated by the development of neuropathy, with up to a third of the direct costs of diabetes attributed to neuropathyrelated morbidity (1). The incidence of diabetic neuropathy increases with duration of diabetes, affecting up to 50% of diabetic patients after 25 years of disease (2). To date, the development of neuroprotective and disease-modifying approaches for diabetic...
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This is the first in a series of articles on presentations at the American Diabetes Association Annual Meeting, San Diego, California, 10–14 June 2005. A number of presentations at the American Diabetes Association (ADA) Annual Meeting discussed aspects of diabetic neuropathy. At a joint European Association for the Study of Diabetes/ADA Symposium, Rury Holman (Oxford, U.K.) reminded the audien...
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Diabetic neuropathy is a common complication of diabetes, especially in cases of poor control or long duration, which is characterized by its clinical polymorphism whose most common form is distal symmetric polyneuropathy. This paper describes the main clinical varieties.
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Diabetic neuropathy in some form or other afflicts a majority of patients with diabetes mellitus. Neuropathic disturbance of sensory, motor or autonomic nerves may occur singly or in combination. Cranial nerve and other mononeuropathies generally resolve spontaneously. Autonomic neuropathy which can result in orthostatic hypotension, gastroparesis diabeticorum, nocturnal diarrhea, atonic bladde...
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At least one in four diabetic patients is affected by peripheral neuropathy. In this study, the MALDI-TOF-MS mass spectra of peptides and proteins were generated following WCX CLINPROT bead fractionation of 39 diabetic peripheral neuropathy (DPN), 39 diabetes mellitus (DM), and 35 control (CON) serum samples. The spectra were analyzed statistically using flexAnalysisTM and Clin-ProtTM bioinform...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2012
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-0193